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1: Biofizika. 2005 Jan-Feb;50(1):107-13. Related Articles, Links: [Structural modifications of the surface of Escherichia coli bacteria and copper-induced permeability of plasma membrane]

[Article in Russian]

Lebedev VS, Volodina LA, Deinega EIu, Fedorov IuI.

The effect of Cu2+ on the structural organization of the cell surface of Escherichia coli bacteria during the induction of conductivity of a plasma membrane was studied. A fluorescent study did not reveal any substantial changes in the microviscosity of lipids by the action of copper ions. At the same time, a substantial reorganization of membrane proteins during plasmolysis was observed. A model of the copper-induced structural reorganization of membrane lipids was constructed, according to which the reorganization leads to the opening in the membrane of channels of nonspecific conductivity for cations. The opening of conductivity channels results from the break of disulfide bonds in critical membrane proteins during the interaction with Cu+, which form either due to the reduction of Cu2+ on specific sites of cell surface or by means of external reducing agents.

PMID: 15759509 [PubMed - indexed for MEDLINE]