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Kuzovnikova T.A., Lebedev V.S., Fedorov Iu.I. Sensitivity of E.coli CuCl2 resistant mutants (Cup R mutants) to fine dust of
copper (FDC) has been studied. Two types of Cup R mutants have been separated on
the basis of sensitivity to synergic composition of streptomycin with CuCl2.
Both types of mutants turned out to be resistant to FDC. Antimicrobial action of
FDC is supposed to be based both on Cu2+ action, and active oxygen forming in
the process of copper dissolution. The given study demonstrated possibilities of
application of ion-resistant mutant strains for studying specifics and
mechanisms of biological action of metals in polycrystal form. |
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