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[Characteristics of copper-induced streptomycin transport in Escherichia coli]
[Article in Russian]
Lebedev VS, Kuzovnikova TA, Kornev AP, Fedorov IuI.
Copper dependent uptake of streptomycin by resting E. coli cells was studied. It was shown that copper stimulates the aminoglycoside uptake only when bacteria possess endogenic energy sources. Additional accumulation of positive charged molecules of the antibiotic is accompanied by partial depolarisation of the membrane, its steady state distribution between cells and the medium corresponding to the resulted value of the membrane potential. On the basis of the data obtained it was suggested that under the influence of copper membrane permeability for streptomycin increases.
PMID: 3311169 [PubMed - indexed for MEDLINE]
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