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Lebedev V.S., Kuzovnikova T.A., Fedorov Iu.I. Combination of metals with antibiotics is a perspective way of
intensification of their action on microbial cells. However, the mechanisms of
synergistic action of such combinations at present is unknown. The correlation
between synergistic action of Cu and Ag salts with antibiotics and
physicochemical properties of the latter was studied on E. coli. It was shown
that among the studied antibiotics (streptomycin, neomycin, tetracycline,
gramicidin C, erythromycin, chloramphenicol) those of them which had positive
charge per molecule ? 2 possessed synergistic action with CuCl2 and AgNO3.
Molecular weight of antibiotics, mechanism of their action and affinity with
lipids were of no or little importance. Taking into account that Cu and Ag at
subbacteriostatic concentrations induce hyperpolarization in E. coli it was
supposed that synergistic action of positively charged drugs with these metals
is due to increasing of binding and penetration rate of the former into the
hyperpolarized bacteria. |
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